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Administration of human β-endorphin (2.5 mg IV bolus) to three subjects with non-insulin-dependent diabetes mellitus (type II) induced prompt and simultaneous increments in the plasma concentrations of insulin and glucagon lasting up to 90 minutes. In contrast to the hyperglycemic response previously observed in normal subjects following β-endorphin, these diabetics showed a progressive decline in plasma glucose throughout the study period. This disparity may be related to a relatively greater release of insulin and lesser rise in glucagon observed in diabetic subjects than in non diabetic subjects. These preliminary findings suggest that further studies to elucidate the role of pancreatic β-endorphin on glucose regulation may be rewarding.
Naltrexone, an opiate antagonist,[link widoczny dla zalogowanych], was administered to young obese (ob/ob) and lean mice for five weeks. Animals had continuous access to food and received 10 mg/kg SC twice daily with equivalent volumes of saline given to controls. The effects on body weight, and pituitary and plasma levels of β-endorphin-like material were measured. Naltrexone-injected obese animals gained weight more slowly over the first three weeks while the weight gain of lean animals was not affected by naltrexone. Plasma levels of β-endorphin were shown to be significantly higher in untreated ob/ob mice and this difference increased with age (4–20 weeks). With naltrexone treatment, plasma levels in +/? mice rose and exceeded those in ob/ob. Saline treatment appeared to be a stress, and pituitary β-endorphins rose 4–6 fold in ob/ob compared with +/?. While naltrexone reduced the levels in ob/ob pituitary towards normal, no effect on β-endorphin levels in pituitary of lean mice was obtained. In vitro studies of effects of the opiate antagonists, naloxone,[link widoczny dla zalogowanych], on insulin secretion by isolated islets provided additional evidence of resistance of lean mice to naloxone relative to ob/ob. (IRI secretion fell only in naloxone treated ob/ob islets.) These observations support the contention that this form of genetic obesity is characterized by elevated endogenous opiate levels and an increased sensitivity to opiate antagonists such as naltrexone or naloxone.
Our bodies produce thousands of chemicals that control impulses necessary for everyday function and sensory navigation. Endorphins, a multi-functional chemical,[link widoczny dla zalogowanych], are emitted to counteract and deal with sensations by transmitting electrical impulses through the body to the nervous system. One of their duties is to help combat pain, much in the same way as morphine or codeine does. Endorphins are also responsible for producing the euphoric feeling one usually experiences after sex, or after an intense work out (often referred to as runners-high). Rigorous work outs not only keep us in shape, but also decrease our stress level due to the endorphins released into the body during the exercise. Other ways to trigger the release of these hormones is through the practice of meditation, acupuncture,[link widoczny dla zalogowanych], and massage therapy.
In a double-blind study, eight patients with symptomatic myocardial ischemia and nine with asymptomatic myocardial ischemia were compared during physical exercise under naloxone (6 mg i.v.) or placebo. Plasma beta-endorphin, cortisol and catecholamines were measured before exercise, during maximal exercise, and 10,[link widoczny dla zalogowanych], 20 and 60 min after exercise. A tourniquet pain test (on the forearm, under control of transcutaneous PO2), and an electrical pain test (intracutaneous electrode placed in the finger with the electrical stimulus under computer control and two-interval forced-choice psycho-physical technique) were performed before exercise as well as immediately after, and 60 min after exercise. Plasma beta-endorphin levels increased significantly (P < 0.01) during exercise in symptomatic and asymptomatic patient groups; every patient showed an increase on beta endorphins during and after exercise. However, the increase found in beta-endorphins during and after exercise was significantly larger (P < 0.01) in asymptomatic than in symptomatic patients. After naloxone,[link widoczny dla zalogowanych], this difference was no longer evident. Angina pectoris during exercise was reported with less latency in symptomatic patients (P < 0.05) and occurred in two of nine asymptomatic patients following naloxone. The time course of plasma cortisol levels exhibited the same pattern as beta-endorphins with the same significant differences between symptomatic and asymptomatic groups. Electrical pain thresholds, though on average higher in asymptomatic patients (2.21 mA vs. 0.79 mA), were not affected by exercise or naloxone. Asymptomatic patients required more time to reach pain thresholds in the tourniquet pain test (P < 0.02). After exercise, tourniquet pain thresholds were significantly lower (P < 0.01) under naloxone compared with placebo. The results suggest that there are quantitative differences in the endorphinergic regulation of pain in patients with symptomatic and asymptomatic myocardial ischemia.
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The infusion of synthetic human β-endorphin (4.5 ng/kg/min) produced the following:
(1) in normal-weight subjects, no significant change of plasma glucose and pancreatic hormones (insulin, C- peptide, and glucagon), a significant plasma free fatty acids (FFA) increase, and a suppression of glycerol plasma levels;
(2) in obese subjects, significant increases of glucose, insulin, C-peptide, and glucagon, a progressive decline of circulating FFA, and no change in glycerol plasma levels. In obese subjects,[link widoczny dla zalogowanych], the intravenous administration of naloxone, given as a bolus (5 mg injected in 5 minutes) before the start of β-endorphin infusion, reduced the plasma glucose response to the opioid by approximately half,[link widoczny dla zalogowanych], annulled the pancreatic hormonal responses, and also reduced the FFA, but not glycerol, response. In normal-weight subjects, naloxone pre treatment did not induce any change of the flat glucose and hormonal responses to β-endorphin, but reversed its effects on circulating FFA and glycerol. These data suggest that physiological elevations of plasma β-endorphin concentrations produce metabolic and hormonal effects in obese subjects significantly different from those occurring in normal-weight subjects; these effects are partially naloxone-sensitive, suggesting the mediation of endogenous opioid receptors.
Investigation has been carried out on 50 samples of fetal pancreata from the 10th to the 32nd week of gestation using the PAP technique. (3-Endorphin-reactive cells were morphometrically recorded by means of the point-counting method.
β-Endorphin reactivity occurred for the first time during the 15th week. During further development, β-endorphin cells were found inside and outside the islets. From the 18th to the 23rd week, these cells were primarily localized in the islet periphery. From the 24th week, they rearranged and occurred in irregular positions mixed with other islet cells. This rearrangement took place with a 4 week delay compared with the basic cell types of the islet organ.
The extrainsular portion of these cells in the exocrine parenchyma varied between 0.3 % in the 27th week and up to 10% in the 22nd week. Concerning the adult human pancreas, it has been suggested whether (3-endorphin cells may be a 6th basic cell type of the islet organ. Previous studies on the coexistence of somatostatin, glucagon and (3-endorphin in the same islet cell and the morphometric analysis would support this assumption.
Endogenous opioids have a tonic inhibitory effect on sympathetic tone and have been implicated in the pathophysiology of vasodepressor syncope. Plasma beta endorphin concentrations increase after vasodepressor syncope induced by exercise or by fasting. AIMS--To take frequent samples for plasma beta endorphin estimation during tilt testing, and to determine whether plasma beta endorphin increased before the start of syncope. PATIENTS--24 patients undergoing tilt testing for investigation of unexplained syncope. SETTING--Tertiary referral center. Blood samples were obtained during 70 degrees head up tilt testing. Plasma beta endorphin concentrations were estimated by radioimmunoassay (mean(SD) pmol/l). RESULTS--Patients with a positive test showed a rise in beta endorphin concentrations before syncope baseline 4.4(1.5) v start of syncope 8.5(3.1), p < 0.002). In contrast, patients with a negative test showed no change in beta endorphin concentrations (baseline 3.4(1.0) v end of test 4.5(2.3), NS). After syncope all patients showed a large secondary increase in beta endorphins (32.3(18.6)). An increase in plasma beta endorphins precedes vasodepressor syncope. This finding supports a pathophysiological role for endogenous opioids in diabetes, obesity and other related disorders.
By Dr George Grant, Ph.D., I.M.D.
See all Articles by Prof. Dr. George GrantSee Prof. Dr,[link widoczny dla zalogowanych]. George Grant&#039,[link widoczny dla zalogowanych];s Expert PageGet Updates on DiabetesGet Updates on Prof. Dr. George Grant Average: 0 Your rating: None Tweet
The common obesity of middle age presents as a set of features that strongly resembles the cardinal symptoms of Cushing's syndrome: obesity of the face (moon face),[link widoczny dla zalogowanych], upper back (buffalo hump) and trunk (pot belly) accompanied by signs of protein-wasting. In non-obese individuals who remain at a constant weight throughout life, the proportion of adipose tissue increases with age at the expense of lean tissue loss. Thus, a mild version of Cushing's syndrome may be part of the normal aging process. A more intense version of this process may occur in overweight adults. Excess and chronic activity of two pituitary hormones may contribute to this adiposity. Both hormones are produced in the same pituitary cell by cleavage from a common large precursor known as pro-opiocortin. One hormone is adrenocorticotrophin (ACTH), which stimulates the release of the glucocorticoid hormones. These hormones promote the conversion of bodily proteins to glucose (gluconeogenesis). The other pituitary hormone is beta-endorphin, a stimulant of appetite that causes the release of insulin. This pancreatic hormone promotes the conversion of glucose and fatty acids to triglycerides (lipogenesis). Three different etiologies are suggested for the excessive and chronic action of these two pituitary hormones: tumors that increase the number of cells that synthesize pro-opiocortin: mutant strains such as the genetically obese mouse (ob/ob) and rat (fa/fa) that produce excessive amounts of ACTH and beta-endorphin: and an age-determined shift in the type of cleavage enzymes present in the pro-opiocortin cell that favors ACTH and beta-endorphin production. Lean body weight loss may be an important contributor to the increased medical problems and mortality of the obese.
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I had never considered myself to be an addict of sugar... until I tried to let go of it. It was hard. It brought up survival panic. However,[link widoczny dla zalogowanych], the Holographic Healing treatments were doing their work so effectively that I started having pain and cramps every time I ate even a little sugar. Natural fruit sugar had no ill effect,[link widoczny dla zalogowanych], only the refined sugar could no longer be tolerated. So I dropped it.
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After a sugar-free month I was amazed and delighted to find out that several physical problems had also dropped. My lifelong severe eczema disappeared as if it had never been. My lifelong hypoglycaemia disappeared. Stress was gone,[link widoczny dla zalogowanych]. Physical strength became enhanced.
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Iraq's interim government has taken legal custody of Saddam Hussein.
Although he still remains physically in the hands of American troops, the former Iraqi dictator is no longer considered a prisoner of war but now a criminal defendant preparing to face war crimes charges.
Three days after gaining sovereignty,[link widoczny dla zalogowanych], the Iraqi government Thursday is scheduled to file charges against Saddam Hussein and 11 of his close associates. Iraqi National Security Adviser Mouwafak al-Rubaie expects a dramatic day when the former dictator and his top associates are brought into open court to face a long list of crimes allegedly committed during the nearly quarter century of Saddam Hussein's rule.
"Starting with homicide to genocide, using chemical weapons in Halabja ... hundreds of thousands of people killed in the mass graves,[link widoczny dla zalogowanych], tens of thousands of people executed in Abu Ghraib prison,[link widoczny dla zalogowanych], starting three wars. And Saddam Hussein is going to be taken away from the court handcuffed,[link widoczny dla zalogowanych]," he said.
A scene that will likely be televised to the world and mark the first time the former Iraqi leader has been seen since American troops were shown giving him a brief medical exam after his capture last December,[link widoczny dla zalogowanych].
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Salem Chalabi,[link widoczny dla zalogowanych], the lawyer overseeing the tribunal set up to try former Iraqi leaders,[link widoczny dla zalogowanych], met with Saddam Hussein and the 11 other defendants Wednesday.
"This was a surreal experience," he said. "He had lost weight. He was not the towering figure that one used to see on TV before. He was visibly nervous because he did not know what was happening. His hair was a bit long, not terribly long but longer than I'd seen before. It was black not gray and he did not have a beard."
After returning to the United States,[link widoczny dla zalogowanych], the man who ran Iraq for the past 14 months met at the White House Wednesday with President Bush, two days after handing sovereignty back to the interim government in Baghdad. Paul Bremer tells CBS he regrets not being able to end the violence in Iraq,[link widoczny dla zalogowanych], which he warns threatens the country's political transition. "They must get security down to a level where the violence allows them to go forward with elections in January,[link widoczny dla zalogowanych]," he said.
The Iraqi government is expected to announce new measures as early as this week to combat the country's insurgency but continues to rely on some 160,000 foreign troops, nearly all of them American, for security.
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NFL betting,[link widoczny dla zalogowanych], International soccer betting, basketball betting, baseball betting and betting on boxing events are a number of the most well-liked events sports bettors place their wagers on. An excellent sportsbook also offers you decreased commission,[link widoczny dla zalogowanych], meaning at 1 place you have to bet $110 to win $100 at one more location where the sportsbooks commission is reduced you might only need to bet $ 105 to win $100, that will make a distinction if you are serious about sports betting. Important to select a sportsbook that is tailored to your needs for instance if you are a high roller you almost certainly do not desire to play at a sportsbook exactly where the highest limit is $ 500 and vice-versa the recreational player would like a location exactly where sports betting is catered to recreational players. So be sure before you start off sports betting to check out our web site,[link widoczny dla zalogowanych], where you'll find fresh data about , news, updates,[link widoczny dla zalogowanych], evaluations and everyday lines.
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A few people bet on sports for fun although other people bet to create big money. Executives devote many hours, day in and day out,[link widoczny dla zalogowanych], in betting on these games to win cash. Do you too wish to win great sum of cash on betting? Would you like to boost your associated probabilities? If yes,[link widoczny dla zalogowanych], you'll find only some internet sites that offer sports betting guidelines. Besides typical way of sports betting, online sports betting have also gained its renown. Online betting could supply you with numerous option possibilities due to the fact online books are competing against one another.You may think that sportsbooks offering large sign up bonuses be a good location to bet, but usually those are the ones that just walk away with your money. You'll find some exeptions needless to say.
These books are effective too as secure. Online betting has produced feasible for many to take uttermost benefit of the motivations supplied by online book suppliers. Nonetheless for betting online, choosing a actual online maker is crucial for successful betting. Due to the fact no individual knows beforehand the way in which the game will play out, it becomes a case of educated generating a guess re which team will finish up winning and by how numerous points. Sports betting might appear to become habit forming and, though, for some,[link widoczny dla zalogowanych], it could be,[link widoczny dla zalogowanych], for a lot of folk it's merely for entertainment and a great deal of fun it is! It permits you a rather more gripping method to have interaction together with your buddies more than a matter in which you have a lot typical ground. Because the final score can't be established till the finish of a game, having a bet placed makes the excitement last all the way thru the game. Even though there is consistently informal betting among pals, most gambles are registered thru what's frequently identified as a "sports book" which is an entity that takes in sports betting, In the U. S. , you can find only four states exactly where sports betting is officially allowed. In other states, you should be prepared to locate a bookie and to put a bet, you have got to be past the age of twenty-one. A few the sports you are able to bet on are horseracing, dog racing,[link widoczny dla zalogowanych], pro hockey, pro baseball, and pro and school football and basketball. Sports betting is typically accepted to become putting down wagers on anything that could be a recognized sport. It is possible to lay a bet on the final score of a game, the amount of points by which a team will win, who will win a boxing match and in what round they're going to become announced the winner.
Gambling on sports has turned into an extremely talked-about past time,[link widoczny dla zalogowanych], every year more people begin to create sports betting picks. A lot of of those folk do so in random demeanor and have no real prospect of achievement. The smart ones have a technique that helps to make sure that sports betting is worthwhile endeavor. The quite first factor which you need to understand about any betting system is it's not going to permit you to win ever single time. You frequently see adverts for betting systems that guarantee that they've a 99% winning %, or some other impractical number. No system can do this and any that guarantee that they are able to are stings.
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An successful betting systems is one that lets you win far more regularly than you lose. This is a crucial point that has to be accepted, you'll have losing gambles, in the event you go in expecting to win every single bet you're going to lose every thing. A system of sports betting picks will allow you to select far more winners than losers, you profit over the lengthy run, not by winning every bet. Before you begin generating sports betting picks you want to ascertain just how much you are ready to bet. You really must have a bankroll you can stand losing, do not ever bet money which you cannot exist with out, it is known as gambling for a reason. Even having a great system there is nonetheless an chance that you may possibly lose. It is also a intelligent thought to restrict the amount that you bet to only half your bankroll at any particular time, if items go negative you wish to be in a position to reconstruct. Sport betting is one thing that is regularly enjoyed by folks all around the planet. Dependent on the country you live, there are types of sports on which you may bet on. Several of them are baseball, basketball,[link widoczny dla zalogowanych], golfing and football.
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By Rich Kriesberg
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We all possess the dual face characteristic of this ancient Roman god. It is a quality I whole-heartedly endorse. As we close out the old year with family gatherings and festivities we usually spend time musing over the happenings of the past year while considering the paths that we want our lives to take in the coming one. The end of the year is primarily about celebrating; and while it is fitting to celebrate the season, you should also take time to celebrate all the hard work you put into attaining the goals you set over the past year. And, if for whatever reason, the year did not turn out as well as you anticipated, you should still celebrate the small victories you enjoyed along the way.
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You play an even more significant role in your life because you are the creator of the events that take place; not only on January 1st,[link widoczny dla zalogowanych], but every single day of the year. Janus could observe the happenings on either side of the gate, but I am sure you would agree that he was powerless to affect the change necessary to ensure that the future would be different from the past. Unlike Janus however, you have a mind that allows you to recall past events, analyze them in the present, and project them into the future. Through this incredible endowment you have been given the ability to do more than just observe your life like a historian or a fortune teller. Like a sculptor,[link widoczny dla zalogowanych], through vision and painstaking hard work, you can shape your life to your will.
I first heard of Janus when I was in the tenth grade during a welcome back address from our vice principal after the Christmas break. Considered the god of gates and doors,[link widoczny dla zalogowanych], this Roman god lent his name to the month of January and had a rather unusual appearance. He was depicted with a double-faced head, each face looking in opposite directions. It is believed that he was depicted in this fashion because of the notion that gates and doors face two directions. In this way one of his faces was able to look backwards while the other looked forward; representing Janus’ contemplation of the happenings of the old year while looking forward to the new one.
Although this is something you should do throughout the entire year, this is traditionally the time of year when most people give thought to the direction they want their lives to take over the next twelve months. They contemplate the goals they want to achieve,[link widoczny dla zalogowanych], the lives they want to impact,[link widoczny dla zalogowanych], the personal relationships they need to cultivate, the business contacts they plan to establish, the changes they need to embrace, and ultimately the person they must become in order to make it all happen.
* What habits did you develop over the past year that served you well?
* What current habits do not support the goals and Li&gt,[link widoczny dla zalogowanych];aspirations you have for the coming year?
* What was the biggest challenge you overcame last year?
* What was your biggest setback?
* What lessons did you learn from them?
A time of celebration
A time for new beginnings
Keep On Pushing!
In his role as the guardian of exits and entrances, Janus was also believed to represent beginnings. He was frequently used to symbolize change and transitions. These include the progression of the past to the future; the transition from one condition to another, or of one vision to another. It is no surprise that he was worshipped during the planting and harvest season,[link widoczny dla zalogowanych], as well as during other important “beginnings” such as marriages and births.
By Devon Harris
See all Articles by Devon HarrisGet Updates on MotivationGet Updates on Devon Harris Average: 0 Your rating: None Tweet
A time for contemplation
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See all Articles by James AndersonGet Updates on Continuing EducationGet Updates on James Anderson Average: 0 Your rating: None Tweet
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If you maintain your composure you can be most effective at coming up with ways to help your students feel as powerful and in charge as they need to feel while preserving the classroom order necessary for successful teaching to take place.
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The Korea Stock Price Index closed up 5.91 points (0.79 percent) to 744.42 points,[link widoczny dla zalogowanych], off a daily high of 748.82 points. Rising issues led decliners, 361 to 318 with 106 stocks unchanged. Volume was at 415.1 million shares worth W1.5 trillion.

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The value of the won closed at W1167.4 against the dollar compared with W1164.8 in the prior session. Yields on benchmark three-year government bonds ended the day at 4.10 percent, compared with 4.12 percent from the previous session.
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I also worked summer basketball camps for Jud Heathcote at Michigan State and Bill Foster at Northwestern. I saw Tom Izzo when he was just beginning his coaching career at Michigan State, along with Mike Deane.

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Can you do that? That may come across as being pretty obvious but I'm constantly amazed at how many coaches think that the world is going to beat a path to their door simply becase they are good at what they do.
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